Brighten up each of your dimming skin cells

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Stem Cell
  • Stem cells are undifferentiated cells that have the capability of growing into body tissues by diversely differentiating

       themselves   as brain, skin, cartilage, nerves, bone, muscle cells, and others.

Stem cell conditioned media
  • human stem cell conditioned media contains various "cell growth factors" that are created during stem cell proliferating

        process, which includes cytokine, fibronectin, collagen and etc.

  • The stem cell culture is widely accepted as base material of premium cosmetics.

         * Cytokine is the glycoprotein that serves as the core of human immune system and is also used as a signaling compound that

            controls and stimulates the body's defense system (It has crucial functions regarding immunity, infectious disease prevention,

            hematogenous functions and cell development).

  • The "stem cell conditioned media" used as a cosmetic base material is divided in many types depending on the ingredient.

  • Among them, since the human induced fat stem cell culture is recognized in terms of its efficacy and safety.

       The active R&D and commercialization are underway.

Effects of stem cell conditioned media
  • Human stem cell conditioned media is a natural gift to the skin's nutrient supply which creates a regenerating effect for

       damaged skin.

 

  • Human stem cell conditioned media contains various "cell growth factors" that are created during stem cell proliferating

       process,  which includes cytokine, fibronectin, collagen and etc.
      The stem cell conditioned media is widely accepted as base material of premium cosmetics.

 
Skin regenerating
· whitening
Anti-Aging
Skin Effect
Wrinkles
Improvement

- Comprehensive skin regenerating

   effect that includes more than 8

   types of cell growth factors.
- In vivo protein that heals various

  humanand animal skin injuries

- Skin-regenerating anti-wrinkle

  effect caused by collagens and

  fibronectins.

- Cell growth factors prevent cell
    extinctions, resulting in delayed
    skin-aging process.

Increase in
collagen
formation
Stronger
epidermis
Less
wrinkle
Natural
formation of
amino-acid
Skin-whitening
and moisturi-
zing effect
Differentiation of Cellonskin human stem cell conditioned media
 
Evaluation Result of  Effectiveness (Jan  2016)

Cellonskin’s stem cell conditioned media is an excellent, trustworthy raw

material of cosmetics, which is directly cultivated by Dièt Medical

Group’s EHL, a professional stem cell research company.

  • The base materials for the Cellonskin human stem cell conditioned media are

       approved by the KFDA (Korea Food and Drug Administration) to have met

       its safety standards for cosmetics material.

       * Conforms to the“Safety Requirements for Human Cell and Tissue
          Conditioned Media” in the Regulations on Cosmetics Safety Standards Etc.
           (Ministry of Food and Drug Safety Notice No. 2000-27)
            → toxicity test,skin stimulation test,genetic toxicity test, skin patch test,etc.

  •  high quality, certified cosmetic substances registered under ICID
     (International Cosmetic Ingredient Dictionary and Handbook),

     - The cosmetic ingredients listed in the ICID are recognized as internationally
        verified ingredients.

  •  reliable substances that are exported worldwide.

The results of assessing the whitening and anti-aging effects of Cellonskin’s stem cell conditioned media

(Jan. 2016, Dermapro Co., Ltd.)

whitening

Melanin refers to a type of dark brown granular pigments that are
present inside skin cells. Skin color is determined by the amount of
melanin present in the skin; the more melanin pigments there are,
the darker the skin is.

Cellonskin’s stem cell conditioned media reduces the amount of
melanin production by 49%, thereby whitening and brightening the skin. 

* It results in 13% more melanin reduction compared to arbutin,
   a major ingredient of whitening cosmetic products.

Before

After

Arbutin

Amount of
melanin production

Tyrosinase activity

Tyrosinase, present in plant and animal tissues, promotes oxidation.
In animal tissues, it is involved in melanin pigment formation.

By inhibiting tyrosinase activity, melanin pigment production can be
suppressed and a whitening effect can be achieved.

* It results in 18% more tyrosinase activity inhibition compared to
   arbutin, a major ingredient of whitening cosmetic products.

Before

After

Arbutin

Dihydroxyphenylalanine (DOPA) becomes easily oxidized in air,
and proceeds to the formation of red pigments and then to the
formation of dark melanin pigments.

By inhibiting DOPA activity, melanin pigment formation can be
prevented.

Before

After

DOPA oxidation activity

anti-wrinkles

Collagen is the main structural protein of various connective tissues
including the skin, bones, teeth and muscles.
A decline in collagen in the dermis layer or hyaluronic acid
(elastic protein) leads to the formation of wrinkles and fine lines.

The stem cell conditioned media boosts collagen production in the
cells and has excellent moisturizing and anti-wrinkle effects.

 

* It leads to 4.7 times more collagen production compared to
   sodium L-ascorbate which prevents discoloration caused by
   oxidation and keeps the original flavor and smell intact.

Amount of
collagen production (mg/g)

Before

After

L-ascorbate

Collagenase is an enzyme that breaks down collagen, a major
structural protein of cells. It reduces the amount of collagen inside
skin cells and causes irregular arrangements, which in turn lowers
skin elasticity and leads to wrinkle formation.

Stem cell conditioned media effectively suppress collagenase
activity and helps maintain firm skin.

Before

After

Collagenase activity

Before  vs.  After
Major cellular growth factors
                     included in the stem cell conditioned media
IGF-1 (Insulin-like Growth Factor-1)

- It promotes the growth of epithelial cells by inducing cell division.
- It promotes the angiogenesis of skin lesion area and induces secretion of regeneration promoting factors.
- It promotes cell proliferation of fibroblasts that synthesize collagen.
- Effectiveness : Anti-aging, Anti-wrinkle, Wound recovery

FGF (Fibroblast Growth Factor)

- It promotes the growth of dermal cells (In particular injured area)
- Increase in collagen formation and less wrinkle
- Hair loss prevention and nerve damage restoration
- Effectiveness : Anti-aging, Anti-wrinkle, Wound recovery, Anti-hair loss

KGF (Keratinocyte Growth Factor)

- It promotes the growth of hair
- Damage treatment
- Effectiveness : Anti-aging, Anti-wrinkle, Wound recovery, Skin rejuvenating

VEGF-A (Vascular Eudothelial Growth Factor-A)

- Promote vascular endothelial cell division (contributes to angiogenesis)
- It promotes the growth of hair
- It maintains the viability of new blood vessels by inhibiting apoptosis
- Effectiveness : Anti-aging, Anti-wrinkle, Wound recovery

IGF-1 (Insulin-like Growth Factor-1)

- It acts as a growth hormone and promotes the proliferation of fibroblasts.
- It improves the cell regeneration in damaged skin cells
- Promotes the proliferation or development of vascular, muscular, bone and nerve cells.
- Effectiveness : Anti-hair loss, Hair-growth, Anti-aging, Anti-wrinkle, Wound recovery

TGF (Transforming Growth Factor)

- It stimulates the growth of dermal cells and cell proliferation.
- Increase in collagen formation and less wrinkle
- Hair loss prevention and nerve damage restoration
- Effectiveness : Anti-hair loss, Hair-growth, Anti-wrinkle, Wound recovery

HGF (Hepatocyte Growth Factor)

- Early developments of the embryonic cells (especially the formation of heart muscles).
- Adult tissue regeneration and wound repair

PDGF (Platelet Derived Growth Factor)

- Controlling the cell growth/division。
- Formations of the blood vessels
- The division of blood vessel growing cells from the original blood vessel fiber.
- An essential element for the cell division of fibroblasts.

DOPA 산화 활성

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